Caloric Restriction Mimetic 2-Deoxyglucose Alleviated Inflammatory Lung Injury via Suppressing Nuclear Pyruvate Kinase M2–Signal Transducer and Activator of Transcription 3 Pathway

Caloric Restriction Mimetic 2-Deoxyglucose Alleviated Inflammatory Lung Injury via Suppressing Nuclear Pyruvate Kinase M2–Signal Transducer and Activator of Transcription 3 Pathway

Inflammation is an energy-intensive process, and caloric restriction (CR) could provide anti-inflammatory benefits. CR mimetics (CRM), such as the glycolytic inhibitor 2-deoxyglucose (2-DG), mimic the beneficial effects of CR without inducing CR-related physiologic disturbance. This study investigat...

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Bibliographic Details
Main Authors: Kai Hu, Yongqiang Yang, Ling Lin, Qing Ai, Jie Dai, Kerui Fan, Pu Ge, Rong Jiang, Jingyuan Wan, Li Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
caloric restriction mimetic
2-deoxyglucose
pyruvate kinase M2
signal transducer and activator of transcription 3
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00426/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00426/full

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