Bolaamphiphile Analogues of 12-bis-THA Cl2 Are Potent Antimicrobial Therapeutics with Distinct Mechanisms of Action against Bacterial, Mycobacterial, and Fungal Pathogens

Bolaamphiphile Analogues of 12-bis-THA Cl2 Are Potent Antimicrobial Therapeutics with Distinct Mechanisms of Action against Bacterial, Mycobacterial, and Fungal Pathogens

ABSTRACT 12-Bis-THA Cl2 [12,12′-(dodecane-1,12-diyl)-bis-(9-amino-1,2,3,4-tetrahydroacridinium) chloride] is a cationic bolalipid adapted from dequalinium chloride (DQC), a bactericidal anti-infective indicated for bacterial vaginosis (BV). Here, we used a structure-activity-relationship study to sh...

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Bibliographic Details
Main Authors: Simona Di Blasio, Maria Clarke, Charlotte K. Hind, Masanori Asai, Louis Laurence, Angelica Benvenuti, Mahnoor Hassan, Dorothy Semenya, DeDe Kwun-Wai Man, Victoria Horrocks, Giorgia Manzo, Sarah Van Der Lith, Carolyn Lam, Eugenio Gentile, Callum Annette, Janine Bosse, Yanwen Li, Barry Panaretou, Paul R. Langford, Brian D. Robertson, Jenny K. W. Lam, J. Mark Sutton, Michael McArthur, A. James Mason
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mSphere
Subjects:
dequalinium chloride
synergy
aminoglycosides
Galleria mellonella
Online Access:https://journals.asm.org/doi/10.1128/msphere.00508-22

Internet

https://journals.asm.org/doi/10.1128/msphere.00508-22

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