Generalizable anchor aptamer strategy for loading nucleic acid therapeutics on exosomes

Generalizable anchor aptamer strategy for loading nucleic acid therapeutics on exosomes

Abstract Clinical deployment of oligonucleotides requires delivery technologies that improve stability, target tissue accumulation and cellular internalization. Exosomes show potential as ideal delivery vehicles. However, an affordable generalizable system for efficient loading of oligonucleotides o...

Full description

Bibliographic Details
Main Authors: Gang Han, Yao Zhang, Li Zhong, Biaobiao Wang, Shuai Qiu, Jun Song, Caorui Lin, Fangdi Zou, Jingqiao Wu, Huanan Yu, Chao Liang, Ke Wen, Yiqi Seow, HaiFang Yin
Format: Article
Language:English
Published: Springer Nature 2024-03-01
Series:EMBO Molecular Medicine
Subjects:
Exosome
Nucleic Acid Therapeutics
Anchor Aptamer
Drug Delivery
SELEX
Online Access:https://doi.org/10.1038/s44321-024-00049-7

Internet

https://doi.org/10.1038/s44321-024-00049-7

Similar Items