Mini-PE, a prime editor with compact Cas9 and truncated reverse transcriptase

Mini-PE, a prime editor with compact Cas9 and truncated reverse transcriptase

Prime editor (PE) is a versatile genome editing tool that does not need extra DNA donors or inducing double-strand breaks. However, in vivo implementation of PE remains a challenge because of its oversized composition. In this study, we screened out the smallest truncated Moloney murine leukemia vir...

Full description

Bibliographic Details
Main Authors: Ting Lan, Huangyao Chen, Chengcheng Tang, Yuhui Wei, Yang Liu, Jizeng Zhou, Zhenpeng Zhuang, Quanjun Zhang, Min Chen, Xiaoqing Zhou, Yue Chi, Jinling Wang, Yu He, Liangxue Lai, Qingjian Zou
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: RNA/DNA Editing
prime editor
miniature
CjCas9
truncated MMLV
AAV
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123002299

Internet

http://www.sciencedirect.com/science/article/pii/S2162253123002299

Similar Items