The Inherited Intestinal Microbiota from Myeloid-Specific ZIP8KO Mice Impairs Pulmonary Host Defense against Pneumococcal Pneumonia

The Inherited Intestinal Microbiota from Myeloid-Specific ZIP8KO Mice Impairs Pulmonary Host Defense against Pneumococcal Pneumonia

Intestinal dysbiosis increases susceptibility to infection through the alteration of metabolic profiles, which increases morbidity. Zinc (Zn) homeostasis in mammals is tightly regulated by 24 Zn transporters. ZIP8 is unique in that it is required by myeloid cells to maintain proper host defense agai...

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Bibliographic Details
Main Authors: Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Sabah Haq, Daniel N. Villageliú, Christi M. Ellis, Niaz Bahar Chowdhury, Amanda E. Ramer-Tait, Jeffrey D. Price, Daren L. Knoell
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Pathogens
Subjects:
zinc transporter
microbiome
gut-lung axis
pneumonia
host defense
Online Access:https://www.mdpi.com/2076-0817/12/5/639

Internet

https://www.mdpi.com/2076-0817/12/5/639

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