The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial

The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial

Abstract Background Critically ill patients undergo extensive physiological alterations that will have impact on antibiotic pharmacokinetics. Up to 60% of intensive care unit (ICU) patients meet the pharmacodynamic targets of beta-lactam antibiotics, with only 30% in fluoroquinolones. Not reaching t...

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Bibliographic Details
Main Authors: A. Abdulla, T. M. J. Ewoldt, N. G. M. Hunfeld, A. E. Muller, W. J. R. Rietdijk, S. Polinder, T. van Gelder, H. Endeman, B. C. P. Koch
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Infectious Diseases
Subjects:
Randomised controlled trial
Therapeutic drug monitoring
Antibiotic
Beta-lactam
Fluoroquinolones
Critically ill patients
Online Access:https://doi.org/10.1186/s12879-020-4781-x

Internet

https://doi.org/10.1186/s12879-020-4781-x

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