Repurposing the Sphingosine-1-Phosphate Receptor Modulator Etrasimod as an Antibacterial Agent Against Gram-Positive Bacteria

Repurposing the Sphingosine-1-Phosphate Receptor Modulator Etrasimod as an Antibacterial Agent Against Gram-Positive Bacteria

New classes of antibiotics are urgently needed in the fight against multidrug-resistant bacteria. Drug repurposing has emerged as an alternative approach to accelerate antimicrobial research and development. In this study, we screened a library of sphingosine-1-phosphate receptor (S1PR) modulators a...

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Bibliographic Details
Main Authors: Matej Zore, Shella Gilbert-Girard, Paola San-Martin-Galindo, Inés Reigada, Leena Hanski, Kirsi Savijoki, Adyary Fallarero, Jari Yli-Kauhaluoma, Jayendra Z. Patel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Microbiology
Subjects:
etrasimod
sphingosine-1-phosphate receptor modulators
repurposing
antimicrobials
biofilms
Staphylococcus aureus
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.926170/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2022.926170/full

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