Repurposing the Sphingosine-1-Phosphate Receptor Modulator Etrasimod as an Antibacterial Agent Against Gram-Positive Bacteria

Repurposing the Sphingosine-1-Phosphate Receptor Modulator Etrasimod as an Antibacterial Agent Against Gram-Positive Bacteria

New classes of antibiotics are urgently needed in the fight against multidrug-resistant bacteria. Drug repurposing has emerged as an alternative approach to accelerate antimicrobial research and development. In this study, we screened a library of sphingosine-1-phosphate receptor (S1PR) modulators a...

Full description

Bibliographic Details
Main Authors:	Matej Zore, Shella Gilbert-Girard, Paola San-Martin-Galindo, Inés Reigada, Leena Hanski, Kirsi Savijoki, Adyary Fallarero, Jari Yli-Kauhaluoma, Jayendra Z. Patel
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Microbiology
Subjects:	etrasimod sphingosine-1-phosphate receptor modulators repurposing antimicrobials biofilms Staphylococcus aureus
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2022.926170/full

Similar Items

Synthesis and Biological Evaluation of Fingolimod Derivatives as Antibacterial Agents
by: Matej Zore, et al.
Published: (2021-07-01)

Screening of FDA-Approved Drugs Using a 384-Well Plate-Based Biofilm Platform: The Case of Fingolimod
by: Shella Gilbert-Girard, et al.
Published: (2020-11-01)

Optimization of a High-Throughput 384-Well Plate-Based Screening Platform with <i>Staphylococcus aureus</i> ATCC 25923 and <i>Pseudomonas aeruginosa</i> ATCC 15442 Biofilms
by: Shella Gilbert-Girard, et al.
Published: (2020-04-01)

Modulating sphingosine 1-phosphate receptor signaling skews intrahepatic leukocytes and attenuates murine nonalcoholic steatohepatitis
by: Chieh-Yu Liao, et al.
Published: (2023-04-01)

Strategies to Prevent Biofilm Infections on Biomaterials: Effect of Novel Naturally-Derived Biofilm Inhibitors on a Competitive Colonization Model of Titanium by <i>Staphylococcus aureus </i>and SaOS-2 Cells
by: Inés Reigada, et al.
Published: (2020-02-01)

Combined Effect of Naturally-Derived Biofilm Inhibitors and Differentiated HL-60 Cells in the Prevention of <i>Staphylococcus aureus</i> Biofilm Formation
by: Inés Reigada, et al.
Published: (2020-11-01)

The Anti-Infectious Role of Sphingosine in Microbial Diseases
by: Yuqing Wu, et al.
Published: (2021-05-01)

Sphingosine basis in milk
by: Slavica Ribar, et al.
Published: (2006-12-01)

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis
by: Kana Masuda-Kuroki, et al.
Published: (2023-09-01)

A real-time high-throughput fluorescence assay for sphingosine kinases
by: Santiago Lima, et al.
Published: (2014-07-01)

A Role of Sphingosine in the Intracellular Survival of Neisseria gonorrhoeae
by: Franziska Solger, et al.
Published: (2020-05-01)

Sphingosine kinase/sphingosine 1-phosphate axis: a new player for insulin-like growth factor-1-induced myoblast differentiation
by: Bernacchioni Caterina, et al.
Published: (2012-07-01)

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking
by: Megan M. Young, et al.
Published: (2016-11-01)

Separation of long-chain bases by thin-layer chromatography; instability of sphingosine
by: Benjamin Weiss, et al.
Published: (1965-01-01)

Sphingosine 1-Phosphate Receptors and Metabolic Enzymes as Druggable Targets for Brain Diseases
by: Sara Grassi, et al.
Published: (2019-07-01)

The Functional Role of Sphingosine Kinase 2
by: Rocio Diaz Escarcega, et al.
Published: (2021-05-01)

Targeting the Sphingosine Kinase/Sphingosine-1-Phosphate Signaling Axis in Drug Discovery for Cancer Therapy
by: Preeti Gupta, et al.
Published: (2021-04-01)

Sphingosine 1-Phosphate Receptor 4 Expression in Colorectal Cancer Patients
by: Suchittra SAMUHASANEETO, et al.
Published: (2016-06-01)

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System
by: Alessandro Cannavo, et al.
Published: (2017-08-01)

Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency
by: Krishan B. Atreya, et al.
Published: (2022-09-01)

Sphingosine 1-Phosphate Signaling at the Skin Barrier Interface
by: Kana Masuda-Kuroki, et al.
Published: (2022-05-01)

Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases
by: Na Wang, et al.
Published: (2023-05-01)

Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells
by: Ling-Wei Hii, et al.
Published: (2021-11-01)

Targeting Sphingosine 1-Phosphate Metabolism as a Therapeutic Avenue for Prostate Cancer
by: Saida Mebarek, et al.
Published: (2023-05-01)

Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate[S]
by: Deanna L. Siow, et al.
Published: (2010-09-01)

Sphingosine 1-Phosphate Signaling and Metabolism in Chemoprevention and Chemoresistance in Colon Cancer
by: Petra Grbčić, et al.
Published: (2020-05-01)

Sphingosine 1-Phosphate and Cancer: Lessons from Thyroid Cancer Cells
by: Kid Törnquist
Published: (2013-05-01)

Surfaceome and Exoproteome Dynamics in Dual-Species Pseudomonas aeruginosa and Staphylococcus aureus Biofilms
by: Inés Reigada, et al.
Published: (2021-06-01)

Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH
by: David Montefusco, et al.
Published: (2022-08-01)

Growth Mode and Physiological State of Cells Prior to Biofilm Formation Affect Immune Evasion and Persistence of <i>Staphylococcus aureus</i>
by: Kirsi Savijoki, et al.
Published: (2020-01-01)

Roles of sphingosine-1-phosphate signaling in cancer
by: Peng Wang, et al.
Published: (2019-11-01)

A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids
by: Timothy Andrew Couttas, et al.
Published: (2020-06-01)

Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model
by: Joseph L. Wilkerson, et al.
Published: (2022-09-01)

Role of Sphingosine-1-Phosphate in Mast Cell Functions and Asthma and Its Regulation by Non-Coding RNA
by: Rohit Saluja, et al.
Published: (2017-05-01)

Sphingosine kinases negatively regulate the expression of matrix metalloproteases (MMP1 and MMP3) and their inhibitor TIMP3 genes via sphingosine 1‐phosphate in extravillous trophoblasts
by: Kirti R. Chahar, et al.
Published: (2021-07-01)

A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke
by: Alexandra Lucaciu, et al.
Published: (2020-08-01)

Corrigendum: Sphingosine 1-Phosphate: A Novel Target for Lung Disorders
by: Sabira Mohammed, et al.
Published: (2018-07-01)

Commentary: Sphingosine-1-phosphate inhibitors are potential therapeutic targets for pulmonary arterial hypertension
by: Naga P Bhavanam, et al.
Published: (2015-10-01)

Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice
by: Sun-Hye Shin, et al.
Published: (2019-03-01)

Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain
by: Gaëlle Dominguez, et al.
Published: (2018-04-01)