Maternal antibiotic exposure increases total islet number and volume in the neonatal pancreas and reduces HbA1c and insulitis in adult female non‐obese diabetic mice

Maternal antibiotic exposure increases total islet number and volume in the neonatal pancreas and reduces HbA1c and insulitis in adult female non‐obese diabetic mice

Abstract Background Early antibiotic treatment changes susceptibility to disease in rodent models for type 1 diabetes, but the impact that gestational antibiotics may have on pancreatic embryogenesis and β cell function later in life is still unknown. Methods Our aim was to determine whether gestati...

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Bibliographic Details
Main Authors: Camilla Hartmann Friis Hansen, Martin Haupt‐Jorgensen, Karsten Buschard, Bente Pakkenberg, Lukasz Krych, Axel Kornerup Hansen
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Clinical and Translational Discovery
Subjects:
Akkermansia
antibiotics
gestation
gut microbiota
non‐obese diabetic mice
pancreatic islet neogenesis
Online Access:https://doi.org/10.1002/ctd2.188

Internet

https://doi.org/10.1002/ctd2.188

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