Non-clinical assessment of safety, biodistribution and tumorigenicity of human mesenchymal stromal cells

Non-clinical assessment of safety, biodistribution and tumorigenicity of human mesenchymal stromal cells

Guidelines regulating the development of advanced therapy medicinal products (ATMPs) request nonclinical data for toxicity, biodistribution and tumorigenicity before mesenchymal stromal cell (MSC) products can be administered in large clinical trials. We assessed the biodistribution/persistence, saf...

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Bibliographic Details
Main Authors: Claudia Thäte, Christiane Woischwill, Gunda Brandenburg, Matthias Müller, Sonja Böhm, Joachim Baumgart
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Toxicology Reports
Subjects:
Mesenchymal stromal cells (MSC)
Toxicity
Biodistribution
Tumorigenicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750021002006

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http://www.sciencedirect.com/science/article/pii/S2214750021002006

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