Therapeutic Targeting of the Macrophage Immune Checkpoint CD47 in Myeloid Malignancies

Therapeutic Targeting of the Macrophage Immune Checkpoint CD47 in Myeloid Malignancies

In recent years, immunotherapies have been clinically investigated in AML and other myeloid malignancies. While most of these are focused on stimulating the adaptive immune system (including T cell checkpoint inhibitors), several key approaches targeting the innate immune system have been identified...

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Bibliographic Details
Main Authors: Mark P. Chao, Chris H. Takimoto, Dong Dong Feng, Kelly McKenna, Phung Gip, Jie Liu, Jens-Peter Volkmer, Irving L. Weissman, Ravindra Majeti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Oncology
Subjects:
CD47
AML
MDS
macrophage
immunotherapy
leukemia stem cell (LSC)
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01380/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01380/full

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