Rescue of synaptic and cognitive functions in polysialic acid-deficient mice and dementia models by short polysialic acid fragments

Rescue of synaptic and cognitive functions in polysialic acid-deficient mice and dementia models by short polysialic acid fragments

Dysregulated cortical expression of the neural cell adhesion molecule (NCAM) and deficits of its associated polysialic acid (polySia) have been found in Alzheimer's disease and schizophrenia. However, the functional role of polySia in cortical synaptic plasticity remains poorly understood. Here...

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Bibliographic Details
Main Authors: Hristo Varbanov, Shaobo Jia, Gaga Kochlamazashvili, Subhrajit Bhattacharya, Manal Ali Buabeid, Mohamed El Tabbal, Hussam Hayani, Stoyan Stoyanov, Weilun Sun, Hauke Thiesler, Iris Röckle, Herbert Hildebrandt, Oleg Senkov, Vishnu Suppiramaniam, Rita Gerardy-Schahn, Alexander Dityatev
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Neurobiology of Disease
Subjects:
NCAM
NMDA receptor
Polysialic acid
Prefrontal cortex
Synaptic plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123000931

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http://www.sciencedirect.com/science/article/pii/S0969996123000931

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