IL-17 inhibits CXCL9/10-mediated recruitment of CD8+ cytotoxic T cells and regulatory T cells to colorectal tumors

IL-17 inhibits CXCL9/10-mediated recruitment of CD8+ cytotoxic T cells and regulatory T cells to colorectal tumors

Abstract Background The IL-17 family cytokines are potent drivers of colorectal cancer (CRC) development. We and others have shown that IL-17 mainly signals to tumor cells to promote CRC, but the underlying mechanism remains unclear. IL-17 also dampens Th1-armed anti-tumor immunity, in part by attra...

Full description

Bibliographic Details
Main Authors: Ju Chen, Xiaoyang Ye, Elise Pitmon, Mengqian Lu, Jun Wan, Evan R. Jellison, Adam J. Adler, Anthony T. Vella, Kepeng Wang
Format: Article
Language:English
Published: BMJ Publishing Group 2019-11-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Interleukin-17
CXCL9
CXCL10
Regulatory T cell
And colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s40425-019-0757-z

Internet

http://link.springer.com/article/10.1186/s40425-019-0757-z

Similar Items