SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing

SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing

Abstract Introduction Small Cell Lung Cancer (SCLC) can be classified into transcriptional subtypes with distinct degrees of neuroendocrine (NE) differentiation. Recent evidence supports plasticity among subtypes with a bias toward adoption of low-NE states during disease progression or upon acquire...

Full description

Bibliographic Details
Main Authors: Esther Redin, Harsha Sridhar, Yingqian A. Zhan, Barbara Pereira Mello, Hong Zhong, Vidushi Durani, Amin Sabet, Parvathy Manoj, Irina Linkov, Juan Qiu, Richard P. Koche, Elisa de Stanchina, Maider Astorkia, Doron Betel, Álvaro Quintanal-Villalonga, Charles M. Rudin
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Journal of Hematology & Oncology
Subjects:
Lung Cancer
SCLC
Plasticity
Epigenetics
Targeted therapies
Online Access:https://doi.org/10.1186/s13045-024-01572-3

Internet

https://doi.org/10.1186/s13045-024-01572-3

Similar Items