Radio-Sensitization of Human Leukaemic MOLT-4 Cells by DNA-Dependent Protein Kinase Inhibitor, NU7026

Radio-Sensitization of Human Leukaemic MOLT-4 Cells by DNA-Dependent Protein Kinase Inhibitor, NU7026

In this paper we describe the influence of NU7026, a specific inhibitor of DNA-dependent protein kinase, phosphoinositide 3-kinase, and ATM-kinase on molecular and cellular mechanisms triggered by ionising irradiation in human T-lymphocyte leukaemic MOLT-4 cells. We studied the effect of this inhibi...

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Bibliographic Details
Main Authors: Aleš Tichý, Eva Novotná, Kamila Ďurišová, Barbora Šalovská, Radka Sedlaříková, Jaroslav Pejchal, Lenka Zárybnická, Jiřina Vávrová, Zuzana Šinkorová, Martina Řezáčová
Format: Article
Language:English
Published: Karolinum Press 2012-01-01
Series:Acta Medica
Subjects:
Inhibitor NU7026
DNA-PK
ATM
PI3-K
Ionizing radiation
Leukaemia
Online Access:https://actamedica.lfhk.cuni.cz/55/2/0066/

Internet

https://actamedica.lfhk.cuni.cz/55/2/0066/

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