The C-Terminal Domain of Nef<sup>mut</sup> Is Dispensable for the CD8<sup>+</sup> T Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles

The C-Terminal Domain of Nef<sup>mut</sup> Is Dispensable for the CD8<sup>+</sup> T Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles

Intramuscular injection of DNA vectors expressing the extracellular vesicle (EV)-anchoring protein Nef<sup>mut</sup> fused at its C-terminus to viral and tumor antigens elicit a potent, effective, and anti-tolerogenic CD8<sup>+</sup> T cell immunity against the heterologous a...

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Bibliographic Details
Main Authors: Chiara Chiozzini, Francesco Manfredi, Flavia Ferrantelli, Patrizia Leone, Andrea Giovannelli, Eleonora Olivetta, Maurizio Federico
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Vaccines
Subjects:
extracellular vesicles
HIV-1 Nef
DNA immunization
CD8<sup>+</sup> T cell immunity
HPV vaccines
SARS-CoV-2 vaccines
Online Access:https://www.mdpi.com/2076-393X/9/4/373

Internet

https://www.mdpi.com/2076-393X/9/4/373

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