The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation

The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation

A polymorphism in the autophagy gene Atg16l1 is associated with susceptibility to inflammatory bowel disease (IBD); however, it remains unclear how autophagy contributes to intestinal immune homeostasis. Here, we demonstrate that autophagy is essential for maintenance of balanced CD4+ T cell respons...

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Bibliographic Details
Main Authors: Agnieszka M Kabat, Oliver J Harrison, Thomas Riffelmacher, Amin E Moghaddam, Claire F Pearson, Adam Laing, Lucie Abeler-Dörner, Simon P Forman, Richard K Grencis, Quentin Sattentau, Anna Katharina Simon, Johanna Pott, Kevin J Maloy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
autophagy
IBD
mucosal immunology
T helper cells
Online Access:https://elifesciences.org/articles/12444

Internet

https://elifesciences.org/articles/12444

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