ALKBH5‐mediated m6A demethylation of TIRAP mRNA promotes radiation‐induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma

ALKBH5‐mediated m6A demethylation of TIRAP mRNA promotes radiation‐induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma

Abstract Background Radiation‐induced hepatic stellate cell (HSC) activation promotes radiation‐induced liver fibrosis (RILF), a complication for hepatocellular carcinoma (HCC) radiotherapy. The demethylase alpha‐ketoglutarate‐dependent dioxygenase alkB homolog 5 (ALKBH5) decreases N6‐methyladenylat...

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Bibliographic Details
Main Authors: Yuhan Chen, Peitao Zhou, Yixun Deng, Xinni Cai, Mingrui Sun, Yining Sun, Dehua Wu
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Clinical and Translational Medicine
Subjects:
hepatic stellate cells
monocytes
N6‐methyladenylate methylation
radiation‐induced liver injury
radiotherapy
Online Access:https://doi.org/10.1002/ctm2.1198

Internet

https://doi.org/10.1002/ctm2.1198

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