Pre-existing TGF-β-specific T-cell immunity in patients with pancreatic cancer predicts survival after checkpoint inhibitors combined with radiotherapy

Pre-existing TGF-β-specific T-cell immunity in patients with pancreatic cancer predicts survival after checkpoint inhibitors combined with radiotherapy

Background Circulating transforming growth factor-β (TGF-β)-specific T cells that recognize TGF-β-expressing immune regulatory cells have been described in patients with cancer. TGF-β-derived peptide vaccination modulates the tumor microenvironment and has shown clinical effects in animal models of...

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Bibliographic Details
Main Authors: Mads Hald Andersen, Özcan Met, Inge Marie Svane, Morten Orebo Holmström, Thomas Landkildehus Lisle, Rasmus Erik Johansson Mortensen, Jane P Hasselby, Gro L Willemoe, Julia Johansen, Dorte L Nielsen, Inna M Chen
Format: Article
Language:English
Published: BMJ Publishing Group 2023-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/3/e006432.full

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https://jitc.bmj.com/content/11/3/e006432.full

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