Ultrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesis

Ultrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesis

The key role of mitochondria in patients affected by amyotrophic lateral sclerosis (ALS) is well documented by electron microscopy studies of motor neurons within spinal cord and brainstem. Nonetheless, recent studies challenged the role of mitochondria placed within the cell body of motor neuron. I...

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Bibliographic Details
Main Authors: Riccardo eRuffoli, Alessia eBartalucci, Alessandro eFrati, Francesco eFornai
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Amyotrophic Lateral Sclerosis
Autophagy
Mitochondria
motor neuron
Electron microscopy
Human Patients
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00341/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00341/full

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