Rotenone-Induced 4-HNE Aggresome Formation and Degradation in HL-1 Cardiomyocytes: Role of Autophagy Flux

Rotenone-Induced 4-HNE Aggresome Formation and Degradation in HL-1 Cardiomyocytes: Role of Autophagy Flux

Reactive oxygen species (ROS) cause oxidative stress by generating reactive aldehydes known as 4-hydroxynonenal (4-HNE). 4-HNE modifies protein via covalent adduction; however, little is known about the degradation mechanism of 4-HNE-adducted proteins. Autophagy is a dynamic process that maintains c...

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Bibliographic Details
Main Authors: Sudha Sharma, Foram Patel, Hosne Ara, Ezra Bess, Alika Shum, Susmita Bhattarai, Utsab Subedi, Daquonte Sanard Bell, Md. Shenuarin Bhuiyan, Hong Sun, Ines Batinic-Haberle, Manikandan Panchatcharam, Sumitra Miriyala
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
oxidative stress
rotenone
autophagy
autophagosome
Mn porphyrin
Online Access:https://www.mdpi.com/1422-0067/23/9/4675

Internet

https://www.mdpi.com/1422-0067/23/9/4675

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