The Plasmodium falciparum Nuclear Protein Phosphatase NIF4 Is Required for Efficient Merozoite Invasion and Regulates Artemisinin Sensitivity

The Plasmodium falciparum Nuclear Protein Phosphatase NIF4 Is Required for Efficient Merozoite Invasion and Regulates Artemisinin Sensitivity

ABSTRACT Artemisinin resistance in Plasmodium falciparum has been associated with a mutation in the NLI-interacting factor-like phosphatase PfNIF4, in addition to the mutations in the Kelch13 protein as the major determinant. We found that PfNIF4 was predominantly expressed at the schizont stage and...

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Bibliographic Details
Main Authors: Xiaotong Zhu, Siqi Li, Chengqi Wang, Yuanchao Yu, Jingjing Wang, Lu He, Faiza Amber Siddiqui, Lumeng Chen, Liying Zhu, Dan Zhou, Junling Qin, Jun Miao, Liwang Cui, Yaming Cao
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
malaria
protein phosphatase
invasion
RNA polymerase II
asexual development
Online Access:https://journals.asm.org/doi/10.1128/mbio.01897-22

Internet

https://journals.asm.org/doi/10.1128/mbio.01897-22

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