Reduced sister chromatid cohesion acts as a tumor penetrance modifier.

Reduced sister chromatid cohesion acts as a tumor penetrance modifier.

Sister chromatid cohesion (SCC) is an important process in chromosome segregation. ESCO2 is essential for establishment of SCC and is often deleted/altered in human cancers. We demonstrate that esco2 haploinsufficiency results in reduced SCC and accelerates the timing of tumor onset in both zebrafis...

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Bibliographic Details
Main Authors: Jun Wang, Holly R Thomas, Yu Chen, Stefanie M Percival, Stephanie C Waldrep, Ryne C Ramaker, Robert G Thompson, Sara J Cooper, Zechen Chong, John M Parant
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010341

Internet

https://doi.org/10.1371/journal.pgen.1010341

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