Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels

Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels

Most transgenic mice used for preclinical evaluation of potential disease-modifying treatments of Alzheimer's disease develop major histopathological features of this disease by several-fold overexpression of the human amyloid precursor protein. We studied the phenotype of three different strai...

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Bibliographic Details
Main Authors: Christoph Köhler, Ulrich Ebert, Karlheinz Baumann, Hannsjörg Schröder
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neurobiology of Disease
Subjects:
Amyloid precursor protein
Gene-targeted
Amyloid deposits
Microglia
Choline acetyltransferase
Apolipoprotein E
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105001257

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http://www.sciencedirect.com/science/article/pii/S0969996105001257

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