Anti‐pruritic effect of isothiocyanates: Potential involvement of toll‐like receptor 3 signaling

Abstract The innate immune system has an emerging role as a mediator of neuro‐immune communication and a therapeutic target for itch. Toll‐like receptor 3 (TLR3) plays an important role in itch, as shown in TLR3 knock‐out mice. In this study, to evaluate effects of TLR3 inhibitors on histamine‐indep...

Full description

Bibliographic Details
Main Authors: Masaki Moriyama, Mitsuhiro Konno, Kanako Serizawa, Natsumi Yuzawa, Yuki Majima, Ikuo Hayashi, Tomohiko Suzuki, Mie Kainoh
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Pharmacology Research & Perspectives
Subjects:
Online Access:https://doi.org/10.1002/prp2.1038