Mechanisms of Resistance to KRAS<sup>G12C</sup> Inhibitors

KRAS is one of the most common human oncogenes, but concerted efforts to produce direct inhibitors have largely failed, earning KRAS the title of “undruggable”. Recent efforts to produce subtype specific inhibitors have been more successful, and several KRAS<sup>G12C</sup> inhibitors hav...

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Bibliographic Details
Main Authors: Victoria Dunnett-Kane, Pantelis Nicola, Fiona Blackhall, Colin Lindsay
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/13/1/151