Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides

Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides

A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III...

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Bibliographic Details
Main Authors: Mikael Elofsson, Tam M. To, Markus K. Dahlgren, J. Mikael Hillgren
Format: Article
Language:English
Published: MDPI AG 2010-08-01
Series:Molecules
Subjects:
type III secretion
Suzuki coupling
Grignard addition
Online Access:http://www.mdpi.com/1420-3049/15/9/6019/

Internet

http://www.mdpi.com/1420-3049/15/9/6019/

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