Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides
A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-08-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/9/6019/ |
| _version_ | 1828738928097624064 |
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| author | Mikael Elofsson Tam M. To Markus K. Dahlgren J. Mikael Hillgren |
| author_facet | Mikael Elofsson Tam M. To Markus K. Dahlgren J. Mikael Hillgren |
| author_sort | Mikael Elofsson |
| collection | DOAJ |
| description | A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors. |
| first_indexed | 2024-04-13T00:12:39Z |
| format | Article |
| id | doaj.art-8650d898142c41238688da8fcd7638e2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T00:12:39Z |
| publishDate | 2010-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8650d898142c41238688da8fcd7638e22022-12-22T03:11:02ZengMDPI AGMolecules1420-30492010-08-011596019603410.3390/molecules15096019Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene AcylhydrazidesMikael ElofssonTam M. ToMarkus K. DahlgrenJ. Mikael HillgrenA focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.http://www.mdpi.com/1420-3049/15/9/6019/type III secretionSuzuki couplingGrignard addition |
| spellingShingle | Mikael Elofsson Tam M. To Markus K. Dahlgren J. Mikael Hillgren Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides Molecules type III secretion Suzuki coupling Grignard addition |
| title | Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides |
| title_full | Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides |
| title_fullStr | Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides |
| title_full_unstemmed | Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides |
| title_short | Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides |
| title_sort | synthesis of 4 2 hydroxyphenyl thiazol 2 yl methanones as potential bioisosteres of salicylidene acylhydrazides |
| topic | type III secretion Suzuki coupling Grignard addition |
| url | http://www.mdpi.com/1420-3049/15/9/6019/ |
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