The Influence of Regional Distribution and Pharmacologic Specificity of GABAAR Subtype Expression on Anesthesia and Emergence

The Influence of Regional Distribution and Pharmacologic Specificity of GABAAR Subtype Expression on Anesthesia and Emergence

Anesthetics produce unconsciousness by modulating ion channels that control neuronal excitability. Research has shown that specific GABAA receptor (GABAAR) subtypes in particular regions of the central nervous system contribute to different hyperpolarizing conductances, and behaviorally to distinct...

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Bibliographic Details
Main Authors: Iris Speigel, Edyta K. Bichler, Paul S. García
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Systems Neuroscience
Subjects:
GABA
receptor trafficking
surface expression
extra-synaptic receptors
tonic inhibition
anesthesia
Online Access:http://journal.frontiersin.org/article/10.3389/fnsys.2017.00058/full

Internet

http://journal.frontiersin.org/article/10.3389/fnsys.2017.00058/full

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