Epigenetic Modifiers Induce Bioactive Phenolic Metabolites in the Marine-Derived Fungus Penicillium brevicompactum

Epigenetic Modifiers Induce Bioactive Phenolic Metabolites in the Marine-Derived Fungus Penicillium brevicompactum

Fungi usually contain gene clusters that are silent or cryptic under normal laboratory culture conditions. These cryptic genes could be expressed for a wide variety of bioactive compounds. One of the recent approaches to induce production of such cryptic fungal metabolites is to use histone deacetyl...

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Bibliographic Details
Main Authors: Seham S. El-Hawary, Ahmed M. Sayed, Rabab Mohammed, Hossam M. Hassan, Mohamed A. Zaki, Mostafa E. Rateb, Tarek A. Mohammed, Elham Amin, Usama Ramadan Abdelmohsen
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Marine Drugs
Subjects:
HDACs inhibitors
Penicillium brevicompactum
phenolic metabolites
nicotinamide
sodium butyrate
antiproliferative
pharmacophore
Online Access:http://www.mdpi.com/1660-3397/16/8/253

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http://www.mdpi.com/1660-3397/16/8/253

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