Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer
Abstract The conversion of tumor-promoting M2 macrophage phenotype to tumor-suppressing M1 macrophages is a promising therapeutic approach for cancer treatment. However, the tumor normally provides an abundance of M2 macrophage stimuli, which creates an M2 macrophage-dominant immunosuppressive micro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01526-2 |
| _version_ | 1817994895075311616 |
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| author | Yongmei Zhao Yuanlin Zheng Yan Zhu Hongyun Li Hongyan Zhu Tianqing Liu |
| author_facet | Yongmei Zhao Yuanlin Zheng Yan Zhu Hongyun Li Hongyan Zhu Tianqing Liu |
| author_sort | Yongmei Zhao |
| collection | DOAJ |
| description | Abstract The conversion of tumor-promoting M2 macrophage phenotype to tumor-suppressing M1 macrophages is a promising therapeutic approach for cancer treatment. However, the tumor normally provides an abundance of M2 macrophage stimuli, which creates an M2 macrophage-dominant immunosuppressive microenvironment. In our study, docetaxel (DTX) as chemotherapeutic modularity was loaded into M1 macrophage-derived exosomes (M1-Exo) with M1 proinflammatory nature to establish DTX-M1-Exo drug delivery system. We found that DTX-M1-Exo induced naïve M0 macrophages to polarize to M1 phenotype, while failed to repolarize to M2 macrophages upon Interleukin 4 restimulation due to impaired mitochondrial function. This suggests that DTX-M1-Exo can achieve long-term robust M1 activation in immunosuppressive tumor microenvironment. The in vivo results further confirmed that DTX-M1-Exo has a beneficial effect on macrophage infiltration and activation in the tumor tissues. Thus, DTX-M1-Exo is a novel macrophage polarization strategy via combined chemotherapy and immunotherapy to achieve great antitumor therapeutic efficacy. |
| first_indexed | 2024-04-14T01:58:07Z |
| format | Article |
| id | doaj.art-8659e8ed245e47aabd9daf730c109d7b |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-14T01:58:07Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-8659e8ed245e47aabd9daf730c109d7b2022-12-22T02:18:56ZengBMCJournal of Nanobiotechnology1477-31552022-08-0120111210.1186/s12951-022-01526-2Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancerYongmei Zhao0Yuanlin Zheng1Yan Zhu2Hongyun Li3Hongyan Zhu4Tianqing Liu5School of Pharmacy, Nantong UniversitySchool of Pharmacy, Nantong UniversitySchool of Pharmacy, Nantong UniversitySchool of Pharmacy, Nantong UniversitySchool of Pharmacy, Nantong UniversityNICM Health Research Institute, Western Sydney UniversityAbstract The conversion of tumor-promoting M2 macrophage phenotype to tumor-suppressing M1 macrophages is a promising therapeutic approach for cancer treatment. However, the tumor normally provides an abundance of M2 macrophage stimuli, which creates an M2 macrophage-dominant immunosuppressive microenvironment. In our study, docetaxel (DTX) as chemotherapeutic modularity was loaded into M1 macrophage-derived exosomes (M1-Exo) with M1 proinflammatory nature to establish DTX-M1-Exo drug delivery system. We found that DTX-M1-Exo induced naïve M0 macrophages to polarize to M1 phenotype, while failed to repolarize to M2 macrophages upon Interleukin 4 restimulation due to impaired mitochondrial function. This suggests that DTX-M1-Exo can achieve long-term robust M1 activation in immunosuppressive tumor microenvironment. The in vivo results further confirmed that DTX-M1-Exo has a beneficial effect on macrophage infiltration and activation in the tumor tissues. Thus, DTX-M1-Exo is a novel macrophage polarization strategy via combined chemotherapy and immunotherapy to achieve great antitumor therapeutic efficacy.https://doi.org/10.1186/s12951-022-01526-2ExosomesMacrophage polarizationTumor immunityMitochondrial functionsBreast cancer |
| spellingShingle | Yongmei Zhao Yuanlin Zheng Yan Zhu Hongyun Li Hongyan Zhu Tianqing Liu Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer Journal of Nanobiotechnology Exosomes Macrophage polarization Tumor immunity Mitochondrial functions Breast cancer |
| title | Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer |
| title_full | Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer |
| title_fullStr | Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer |
| title_full_unstemmed | Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer |
| title_short | Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer |
| title_sort | docetaxel loaded m1 macrophage derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer |
| topic | Exosomes Macrophage polarization Tumor immunity Mitochondrial functions Breast cancer |
| url | https://doi.org/10.1186/s12951-022-01526-2 |
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