In vitro human helper T-cell assay to screen antibody drug candidates for immunogenicity

In vitro human helper T-cell assay to screen antibody drug candidates for immunogenicity

Monoclonal antibody (mAb) drugs offer a number of valuable treatments. Many newly developed mAb drugs include artificial modification of amino acid sequences from human origin, which may cause higher immunogenicity to induce anti-drug antibodies (ADA). If the immunogenicity of a new candidate can be...

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Bibliographic Details
Main Authors: Shunsuke Ito, Tatsuya Ikuno, Masayuki Mishima, Mariko Yano, Toshiko Hara, Taichi Kuramochi, Zenjiro Sampei, Tetsuya Wakabayashi, Mitsuyasu Tabo, Shuichi Chiba, Chiyomi Kubo
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Immunotoxicology
Subjects:
immunogenicity
helper t cells
t-cell epitopes
flow cytometry
antigen presentation
monoclonal antibody drugs
stimulation index
bromodeoxyuridine
Online Access:http://dx.doi.org/10.1080/1547691X.2019.1604586

Internet

http://dx.doi.org/10.1080/1547691X.2019.1604586

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