In vitro human helper T-cell assay to screen antibody drug candidates for immunogenicity

In vitro human helper T-cell assay to screen antibody drug candidates for immunogenicity

Monoclonal antibody (mAb) drugs offer a number of valuable treatments. Many newly developed mAb drugs include artificial modification of amino acid sequences from human origin, which may cause higher immunogenicity to induce anti-drug antibodies (ADA). If the immunogenicity of a new candidate can be...

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Bibliographic Details
Main Authors:	Shunsuke Ito, Tatsuya Ikuno, Masayuki Mishima, Mariko Yano, Toshiko Hara, Taichi Kuramochi, Zenjiro Sampei, Tetsuya Wakabayashi, Mitsuyasu Tabo, Shuichi Chiba, Chiyomi Kubo
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2019-01-01
Series:	Journal of Immunotoxicology
Subjects:	immunogenicity helper t cells t-cell epitopes flow cytometry antigen presentation monoclonal antibody drugs stimulation index bromodeoxyuridine
Online Access:	http://dx.doi.org/10.1080/1547691X.2019.1604586

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