Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis.

Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis.

Substantial evidence implicates abnormal protein kinase function in various aspects of Parkinson’s disease (PD) etiology. Elevated phosphorylation of the PD-defining pathological protein, α-synuclein, correlates with its aggregation and toxic accumulation in neurons, whilst genetic missense mutation...

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Bibliographic Details
Main Authors: Nicolas eDzamko, Jinxia eZhou, Yue eHuang, Glenda eHalliday
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Brain
kinase
JNK
LRRK2
MAPK
PINK1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00057/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00057/full

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