Sigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors

Sigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors

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The analgesic effects of sigma-1 antagonists are undisputed, but the effects of sigma-1 agonists on pain are not well studied. Here, we used a mouse model to show that the administration of the sigma-1 agonists dextromethorphan (a widely used antitussive drug), PRE-084 (a standard sigma-1 ligand), a...

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Bibliographic Details
Main Authors: M. Carmen Ruiz-Cantero, Miguel Á. Huerta, Miguel Á. Tejada, Miriam Santos-Caballero, Eduardo Fernández-Segura, Francisco J. Cañizares, José M. Entrena, José M. Baeyens, Enrique J. Cobos
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Sigma-1 receptor
Prostaglandin E2
Plantar incision
Resiniferatoxin
TRPV1
Neutrophil
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222301332X

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http://www.sciencedirect.com/science/article/pii/S075333222301332X

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