Impact of the Myosin Modulator Mavacamten on Force Generation and Cross‐Bridge Behavior in a Murine Model of Hypercontractility

Impact of the Myosin Modulator Mavacamten on Force Generation and Cross‐Bridge Behavior in a Murine Model of Hypercontractility

Background Recent studies suggest that mavacamten (Myk461), a small myosin‐binding molecule, decreases hypercontractility in myocardium expressing hypertrophic cardiomyopathy‐causing missense mutations in myosin heavy chain. However, the predominant feature of most mutations in cardiac myosin bindin...

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Bibliographic Details
Main Authors: Ranganath Mamidi, Jiayang Li, Chang Yoon Doh, Sujeet Verma, Julian E. Stelzer
Format: Article
Language:English
Published: Wiley 2018-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac muscle
cardiomyopathy
contractile function
cross‐bridge behavior
Mavacamten
myocardium
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.009627

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.118.009627

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