D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1

D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1

The clinical manifestation of the recent pandemic COVID-19, caused by the novel SARS-CoV-2 virus, varies from mild to severe respiratory illness. Although environmental, demographic and co-morbidity factors have an impact on the severity of the disease, contribution of the mutations in each of the v...

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Bibliographic Details
Main Authors: Suchetana Gupta, Ditipriya Mallick, Kumarjeet Banerjee, Shrimon Mukherjee, Soumyadev Sarkar, Sonny TM Lee, Partha Basuchowdhuri, Siddhartha S Jana
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
ORF3a
SARS-CoV-2
Molecular dynamics simulation
Graph theory
Mutation
Caveolin-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022000241

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http://www.sciencedirect.com/science/article/pii/S2001037022000241

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