Afatinib Mediates Autophagic Degradation of ORAI1, STIM1, and SERCA2, Which Inhibits Proliferation of Non–Small Cell Lung Cancer Cells

Afatinib Mediates Autophagic Degradation of ORAI1, STIM1, and SERCA2, Which Inhibits Proliferation of Non–Small Cell Lung Cancer Cells

Background The expression of calcium signaling pathway molecules is altered in various carcinomas, which are related to the proliferation and altered characteristics of cancer cells. However, changes in calcium signaling in anti-cancer drug-resistant cells (bearing a T790M mutation in epidermal grow...

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Bibliographic Details
Main Authors: Mi Seong Kim, So Hui Kim, Sei-Hoon Yang, Min Seuk Kim
Format: Article
Language:English
Published: The Korean Academy of Tuberculosis and Respiratory Diseases 2022-04-01
Series:Tuberculosis and Respiratory Diseases
Subjects:
afatinib
calcium channels
non–small cell lung
autophagy
Online Access:http://www.e-trd.org/upload/pdf/trd-2021-0095.pdf

Internet

http://www.e-trd.org/upload/pdf/trd-2021-0095.pdf

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