SENP3‐mediated TIP60 deSUMOylation is required for DNA‐PKcs activity and DNA damage repair

SENP3‐mediated TIP60 deSUMOylation is required for DNA‐PKcs activity and DNA damage repair

Abstract The activation of DNA‐dependent kinase (DNA‐PKcs) upon DNA damage contains a cascade of reactions, covering acetylation by TIP60, binding with Ku70/80, and autophosphorylation. However, how cells regulate TIP60‐mediated acetylation of DNA‐PKcs and the following DNA‐PKcs activation upon DNA...

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Bibliographic Details
Main Authors: Yang Han, Xin Huang, Xiaoyu Cao, Yuchen Li, Lei Gao, Jin Jia, Gang Li, Hejiang Guo, Xiaochang Liu, Hongling Zhao, Hua Guan, Pingkun Zhou, Shanshan Gao
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:MedComm
Online Access:https://doi.org/10.1002/mco2.123

Internet

https://doi.org/10.1002/mco2.123

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