A randomized Phase I pre-operative window trial of transdermal endoxifen in women planning mastectomy: Evaluation of dermal safety, intra-mammary drug distribution, and biologic effects

A randomized Phase I pre-operative window trial of transdermal endoxifen in women planning mastectomy: Evaluation of dermal safety, intra-mammary drug distribution, and biologic effects

Breast cancer prevention only requires local exposure of the breast to active drug. However, oral preventive agents entail systemic exposure, causing adverse effects that limit acceptance by high-risk women. Drug-delivery through the breast skin is an attractive option, but requires demonstration of...

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Bibliographic Details
Main Authors: Oukseub Lee, Latifa A. Bazzi, Yanfei Xu, Erik Pearson, Minhua Wang, Omid Hosseini, Azza M. Akasha, Jennifer Nam Choi, Scott Karlan, Melissa Pilewskie, Masha Kocherginsky, Kelly Benante, Thomas Helland, Gunnar Mellgren, Eileen Dimond, Marjorie Perloff, Brandy M. Heckman-Stoddard, Seema A. Khan
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Transdermal delivery
Breast
Drug distribution
Endoxifen
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223019030

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http://www.sciencedirect.com/science/article/pii/S0753332223019030

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