Chronic inhibition of the mitochondrial ATP synthase in skeletal muscle triggers sarcoplasmic reticulum distress and tubular aggregates

Chronic inhibition of the mitochondrial ATP synthase in skeletal muscle triggers sarcoplasmic reticulum distress and tubular aggregates

Abstract Tubular aggregates (TA) are honeycomb-like arrays of sarcoplasmic-reticulum (SR) tubules affecting aged glycolytic fibers of male individuals and inducing severe sarcomere disorganization and muscular pain. TA develop in skeletal muscle from Tubular Aggregate Myopathy (TAM) patients as well...

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Main Authors: Cristina Sánchez-González, Juan Cruz Herrero Martín, Beñat Salegi Ansa, Cristina Núñez de Arenas, Brina Stančič, Marta P. Pereira, Laura Contreras, José M. Cuezva, Laura Formentini
Format: Article
Language:English
Published: Nature Publishing Group 2022-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05016-z

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https://doi.org/10.1038/s41419-022-05016-z

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