Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability

Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability

Abstract Tumor cells must rewire nucleotide synthesis to satisfy the demands of unbridled proliferation. Meanwhile, they exhibit augmented reactive oxygen species (ROS) production which paradoxically damages DNA and free deoxy-ribonucleoside triphosphates (dNTPs). How these metabolic processes are i...

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Bibliographic Details
Main Authors: Minhui Ye, Yingzhe Fang, Lu Chen, Zemin Song, Qing Bao, Fei Wang, Hao Huang, Jin Xu, Ziwen Wang, Ruijing Xiao, Meng Han, Song Gao, Hudan Liu, Baishan Jiang, Guoliang Qing
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46572-6

Internet

https://doi.org/10.1038/s41467-024-46572-6

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