Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion

Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion

Background & Aims: Hepatocellular carcinoma (HCC) mainly develops from chronic hepatitis. Metabolic dysfunction-associated steatohepatitis (MASH) has gradually become the main pathogenic factor for HCC given the rising incidence of obesity and metabolic diseases. 15-Hydroxyprostaglandin dehy...

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Main Authors: Xichen Hu, Tadahito Yasuda, Noriko Yasuda-Yosihara, Atsuko Yonemura, Terumasa Umemoto, Yutaka Nakachi, Kohei Yamashita, Takashi Semba, Kota Arima, Tomoyuki Uchihara, Akiho Nishimura, Luke Bu, Lingfeng Fu, Feng Wei, Jun Zhang, Yilin Tong, Huaitao Wang, Kazuya Iwamoto, Takaichi Fukuda, Hayato Nakagawa, Koji Taniguchi, Yuji Miyamoto, Hideo Baba, Takatsugu Ishimoto
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:JHEP Reports
Subjects:
Chronic inflammation
CD8+ T-cell exhaustion
Cyclooxygenase 2
15-Hydroxyprostaglandin dehydrogenase
Metabolic dysfunction associated steatohepatitis-hepatocellular carcinoma
Nonalcoholic steatohepatitis-hepatocellular carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923002239

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