Targeting Ca<sup>2+</sup> and Mitochondrial Homeostasis by Antipsychotic Thioridazine in Leukemia Cells

Targeting Ca<sup>2+</sup> and Mitochondrial Homeostasis by Antipsychotic Thioridazine in Leukemia Cells

Mitochondria have pivotal roles in cellular physiology including energy metabolism, reactive oxygen species production, Ca<sup>2+</sup> homeostasis, and apoptosis. Altered mitochondrial morphology and function is a common feature of cancer cells and the regulation of mitochondrial homeos...

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Bibliographic Details
Main Authors: Vivian W. R. Moraes, Vivian M. Santos, Eloah R. Suarez, Letícia S. Ferraz, Rayssa de Mello Lopes, Giuliana P. Mognol, Joana D. Campeiro, João A. Machado-Neto, Fabio D. Nascimento, Mirian A. F. Hayashi, Ivarne L. S. Tersariol, Donald D. Newmeyer, Tiago Rodrigues
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Life
Subjects:
apoptosis
calcium
endoplasmic reticulum stress
leukemia
mitochondria
phenothiazine
Online Access:https://www.mdpi.com/2075-1729/12/10/1477

Internet

https://www.mdpi.com/2075-1729/12/10/1477

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