Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2
Abstract Herpes simplex virus (HSV) receptor engagement activates phospholipid scramblase triggering Akt translocation to the outer leaflet of the plasma membrane where its subsequent phosphorylation promotes viral entry. We hypothesize that this previously unrecognized outside-inside signaling path...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04067-4 |