Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironment

Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironment

Abstract Epithelial-to-mesenchymal transition (EMT) is associated with tumor initiation, metastasis, and drug resistance. However, the mechanisms underlying these associations are largely unknown. We studied several tumor types to identify the source of EMT gene expression signals and a potential me...

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Bibliographic Details
Main Authors: Peter M. Szabo, Amir Vajdi, Namit Kumar, Michael Y. Tolstorukov, Benjamin J. Chen, Robin Edwards, Keith L. Ligon, Scott D. Chasalow, Kin-Hoe Chow, Aniket Shetty, Mohan Bolisetty, James L. Holloway, Ryan Golhar, Brian A. Kidd, Philip Ansumana Hull, Jeff Houser, Logan Vlach, Nathan O. Siemers, Saurabh Saha
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-28480-9

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https://doi.org/10.1038/s41598-023-28480-9

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