Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats

Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats

Dimethyl nitrosamine (DMN) is a known hepatotoxin, carcinogen, and mutagen. This study is therefore carried out to investigate the therapeutic effects of syringic acid (SYRA) and ascorbic acid (ASCA) in DMN-induced hepatic injury in rats. Following DMN administrations, malondialdehyde (MDA), nitric...

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Bibliographic Details
Main Authors: Olubisi E. Adeyi, Oluwatobi T. Somade, Babajide O. Ajayi, Adewale S. James, Akindele O. Adeyi, Zainab M. Olayemi, Nafisat B. Tella
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Liver injury
Inflammation
Oxidative stress
Dimethyl nitrosamine
Syringic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580823000092

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http://www.sciencedirect.com/science/article/pii/S2405580823000092

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