Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats
Dimethyl nitrosamine (DMN) is a known hepatotoxin, carcinogen, and mutagen. This study is therefore carried out to investigate the therapeutic effects of syringic acid (SYRA) and ascorbic acid (ASCA) in DMN-induced hepatic injury in rats. Following DMN administrations, malondialdehyde (MDA), nitric...
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| Language: | English |
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Elsevier
2023-03-01
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| Series: | Biochemistry and Biophysics Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580823000092 |
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| author | Olubisi E. Adeyi Oluwatobi T. Somade Babajide O. Ajayi Adewale S. James Akindele O. Adeyi Zainab M. Olayemi Nafisat B. Tella |
| author_facet | Olubisi E. Adeyi Oluwatobi T. Somade Babajide O. Ajayi Adewale S. James Akindele O. Adeyi Zainab M. Olayemi Nafisat B. Tella |
| author_sort | Olubisi E. Adeyi |
| collection | DOAJ |
| description | Dimethyl nitrosamine (DMN) is a known hepatotoxin, carcinogen, and mutagen. This study is therefore carried out to investigate the therapeutic effects of syringic acid (SYRA) and ascorbic acid (ASCA) in DMN-induced hepatic injury in rats. Following DMN administrations, malondialdehyde (MDA), nitric oxide (NO) and reduced glutathione (GSH) as well as activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) were significantly increased. Also significantly increased were levels of tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Following treatment with SYRA and ASCA, the activities of ALT, AST, GPx, CAT and SOD, as well as MDA, GSH, TNF-α, IL-1β, and NFkB levels were significantly reduced. Overall, both treatments were effective, but SYRA had a better therapeutic effect than ASCA. Therefore, this promising potential of SYRA can be taken advantage of in the treatment of DMN-induced hepatic injury. |
| first_indexed | 2024-04-10T16:07:11Z |
| format | Article |
| id | doaj.art-866fe2514e8f4d38b01b8d5acd7f33a2 |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-04-10T16:07:11Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-866fe2514e8f4d38b01b8d5acd7f33a22023-02-10T04:22:50ZengElsevierBiochemistry and Biophysics Reports2405-58082023-03-0133101428Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in ratsOlubisi E. Adeyi0Oluwatobi T. Somade1Babajide O. Ajayi2Adewale S. James3Akindele O. Adeyi4Zainab M. Olayemi5Nafisat B. Tella6Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, NigeriaDepartment of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria; Corresponding author. Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.Department of Chemical Sciences, Faculty of Natural Sciences, Ajayi Crowther University, Oyo, NigeriaDepartment of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, NigeriaAnimal Physiology Unit, Department of Zoology, University of Ibadan, Ibadan, NigeriaDepartment of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, NigeriaDepartment of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, NigeriaDimethyl nitrosamine (DMN) is a known hepatotoxin, carcinogen, and mutagen. This study is therefore carried out to investigate the therapeutic effects of syringic acid (SYRA) and ascorbic acid (ASCA) in DMN-induced hepatic injury in rats. Following DMN administrations, malondialdehyde (MDA), nitric oxide (NO) and reduced glutathione (GSH) as well as activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) were significantly increased. Also significantly increased were levels of tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Following treatment with SYRA and ASCA, the activities of ALT, AST, GPx, CAT and SOD, as well as MDA, GSH, TNF-α, IL-1β, and NFkB levels were significantly reduced. Overall, both treatments were effective, but SYRA had a better therapeutic effect than ASCA. Therefore, this promising potential of SYRA can be taken advantage of in the treatment of DMN-induced hepatic injury.http://www.sciencedirect.com/science/article/pii/S2405580823000092Liver injuryInflammationOxidative stressDimethyl nitrosamineSyringic acid |
| spellingShingle | Olubisi E. Adeyi Oluwatobi T. Somade Babajide O. Ajayi Adewale S. James Akindele O. Adeyi Zainab M. Olayemi Nafisat B. Tella Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats Biochemistry and Biophysics Reports Liver injury Inflammation Oxidative stress Dimethyl nitrosamine Syringic acid |
| title | Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats |
| title_full | Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats |
| title_fullStr | Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats |
| title_full_unstemmed | Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats |
| title_short | Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats |
| title_sort | syringic acid demonstrates better anti apoptotic anti inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro inflammatory and apoptotic markers in dmn induced hepatotoxicity in rats |
| topic | Liver injury Inflammation Oxidative stress Dimethyl nitrosamine Syringic acid |
| url | http://www.sciencedirect.com/science/article/pii/S2405580823000092 |
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