Investigations on Anticancer Potentials by DNA Binding and Cytotoxicity Studies for Newly Synthesized and Characterized Imidazolidine and Thiazolidine-Based Isatin Derivatives

Investigations on Anticancer Potentials by DNA Binding and Cytotoxicity Studies for Newly Synthesized and Characterized Imidazolidine and Thiazolidine-Based Isatin Derivatives

Imidazolidine and thiazolidine-based isatin derivatives (IST-01–04) were synthesized, characterized, and tested for their interactions with ds-DNA. Theoretical and experimental findings showed good compatibility and indicated compound–DNA binding by mixed mode of interactions. The evaluated binding...

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Bibliographic Details
Main Authors: Nasima Arshad, Muhammad Ismail Mir, Fouzia Perveen, Aneela Javed, Memona Javaid, Aamer Saeed, Pervaiz Ali Channar, Shahid Iqbal Farooqi, Saad Alkahtani, Jamshed Anwar
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
isatin derivatives
DNA binding studies
binding correlations
cell line activity
anticancer drug candidacy
Online Access:https://www.mdpi.com/1420-3049/27/2/354

Internet

https://www.mdpi.com/1420-3049/27/2/354

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