Tissue-nonspecific Alkaline Phosphatase Regulates Purinergic Transmission in the Central Nervous System During Development and Disease

Tissue-nonspecific Alkaline Phosphatase Regulates Purinergic Transmission in the Central Nervous System During Development and Disease

Tissue-nonspecific alkaline phosphatase (TNAP) is one of the four isozymes in humans and mice that have the capacity to hydrolyze phosphate groups from a wide spectrum of physiological substrates. Among these, TNAP degrades substrates implicated in neurotransmission. Transgenic mice lacking TNAP act...

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Bibliographic Details
Main Authors: Álvaro Sebastián-Serrano, Laura de Diego-García, Carlos Martínez-Frailes, Jesús Ávila, Herbert Zimmermann, José Luis Millán, María Teresa Miras-Portugal, Miguel Díaz-Hernández
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
TNAP
Development
Neurodegenerative diseases
Pyridoxal phosphate
ATP
P2X7R
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037014000543

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http://www.sciencedirect.com/science/article/pii/S2001037014000543

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